Overview:

Our product comprises of Aceclofenac and Paracetamol which is used to relieve mild to moderate pain. Paracetamol has analgesic and antipyretic properties. Aceclofenac is a non-steroidal agent with marked anti-inflammatory properties. It is largely based on the inhibition to prostaglandin synthesis.

Indications:

• Anti-inflammatory, antipyretic agents used to treat pain and swelling.
• For the relief of mild to moderate pain and febrile conditions, e.g. headache, toothache, colds, influenza, rheumatic pain and dysmenorrhoea.
• For its antipyretic action.

Side Effects:

Nausea

Allergic reactions

Skin rashes

Headache

Warning & Precautions:

Precaution should be taken in patients with - GI disease; renal or hepatic impairment; alcohol-dependent patients; asthma or allergic disorders; hemorrhagic disorders; hypertension; cardiac impairment.
Elderly: Monitor renal and hepatic function and blood counts during long term treatment.
Persistently elevated may require drug withdrawal.

Pregnant & Lactating Women:

Pregnant and lactating women should take this medication only under the prescription of the physician.

Pharmacology:

Pharmacodynamics Properties of Aceclofenac:
Aceclofenac is a non-steroidal agent with marked anti-inflammatory and analgesic properties. The mode of action of aceclofenac is largely based on the inhibition to prostaglandin synthesis. Aceclofenac is a potent inhibitor of the enzyme cyclo-oxygenase, which is involved in the production of prostaglandins.
Paracetamol
Paracetamol has analgesic and antipyretic properties. Paracetamol effects are thought to be related to inhibition of prostaglandin synthesis.
Pharmacokinetic Properties of Aceclofenac:
Aceclofenac is rapidly and completely absorbed as unchanged drug. Peak plasma concentrations are reached approximately 1.25 to 3.00 hours following ingestion. Aceclofenac penetrates into the synovial fluid, where the concentrations reach approximately 57% of those in plasma. The volume of distribution is approximately 25 L.
The mean plasma elimination half-life is around 4 hours. Aceclofenac is highly protein- bound Aceclofenac circulates mainly as unchanged drug hydroxyaceclofenac is the main metabolite detected in plasma.
Paracetamol:
Absorption:
Paracetamol is readily absorbed from the gastrointestinal tract.
Distribution:
Peak plasma concentrations occur about 10 to 60minutes after oral doses. Paracetamol is distributed into most body tissues. It crosses the placenta and is present in breast milk. Plasma-protein binding is negligible at usual therapeutic concentrations but increases with increasing concentrations.
Metabolism:
It is metabolized in the liver.
Elimination:
It is excreted in the urine, mainly as the glucuronide and sulfate conjugates. The elimination half-life varies from about 1 to 4 hours.